Gainesville's MSA ranked as the No. 1 place to live in the 2007 edition of Cities Ranked and Rated. National Geographic Adventure has ranked Gainesville as one of the "best places to live and play" in the United States.
Newberry's city limits abut the SW border of Gainesville. Much of Gainesville's growth follows SR-26 from I-75 to Newberry. Both residential and commercial development occur along this rapidly growing corridor.